Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Nitrogen Hydrate Cage Occupancy and Bulk Modulus Inferred from Density Functional Theory-Derived Cell Parameters
Gas clathrate hydrate solid materials, ubiquitous in nature as found either on the ocean floor, permafrost on the Earth, or in extraterrestrial planets and comets, are also technologically relevant, for example, in energy storage or carbon dioxide sequestration. Nitrogen hydrate, in particular, is ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
Genotypic and phenotypic evolution of a Pseudomonas aeruginosa ST395 strain during 11-year in hospital spread.
P. aeruginosa is an opportunistic pathogen responsible of hospital-acquired infections in immunocompromised patients. Although in-host evolution of P. aeruginosa is well documented, little is known about this pathogen evolution during its spread on a hospital scale. The high-risk multidrug resistant ...
Pollen analysis - Saint-Bonnet-de-Chavagne (F-26), Le Châtelard
Archaeological site: lime mortar from a wall. Only one palynological sample. Test in the mortar of the fortified house.
World influence of infectious diseases from Wikipedia network analysis
We consider the network of 5416537 articles of English Wikipedia of 2017. Using the recent reduced Google matrix (REGOMAX) method we construct the reduced network of 230 articles (nodes) of infectious diseases and 195 articles of world countries. This method generates the reduced directed network ...
Cholera database of Democratic Republic of Congo
This database contains information on the weekly monitoring of cholera in the health zones of the DRC since 2000.
Reactivity of CuI and CuBr toward Dialkyl Sulfides RSR: From Discrete Molecular Cu4I4S4 and Cu8I8S6 Clusters to Luminescent Copper(I) Coordination Polymers
The CuX salts (X = I, Br) react with SR2 to form molecular clusters of the types [(R2S)4(Cu4I4)] and [(R2S)6(Cu8I8)] or to give 1D polymers and 2D metal−organic frameworks. The cluster nuclearity and connectivity as well as the dimensionality of these compounds depend on the steric demand of SR2, ...
Access
Discipline
- Infectious diseases
- Architecture
- Materials science, characterization & testing
- Environmental sciences
- Paleontology
- Archaeology
- Geosciences, multidisciplinary
- Geography, physical
- Geology
- Ecology
- Limnology
- Biodiversity conservation
- Crystallography
- Astronomy & astrophysics
- Water resources
- Meteorology & atmospheric sciences
- Geochemistry & geophysics
- Physics, atomic, molecular & chemical
- Chemistry, organic
- Microbiology
- History
- Mineralogy
- Multidisciplinary sciences
- Materials science, multidisciplinary
- Cell biology
- Plant sciences
- Spectroscopy
- Chemistry, inorganic & nuclear
- Engineering, electrical & electronic
- Chemistry, analytical
- Computer science, artificial intelligence
- Agronomy
- Chemistry, physical
- Physics, mathematical
- Geography
- Parasitology
- Engineering, environmental
- Health care sciences & services
- Computer science, information systems
- Computer science, software engineering
- Electrochemistry
- Energy & fuels
- Engineering, industrial
- Ornithology
- Biochemistry & molecular biology
- Forestry
- Mycology
- Engineering, mechanical
- Marine & freshwater biology
- Oceanography
- Mathematical & computational biology
- Humanities, multidisciplinary
- Pathology
- Behavioral sciences
- Computer science, theory & methods
- Engineering, multidisciplinary
- Instruments & instrumentation
- Oncology
- Robotics
- Zoology
- Pharmacology & pharmacy
- Entomology
- Linguistics
- Remote sensing
- Materials science, composites
- Medical informatics
- Medieval & renaissance studies
- Anatomy & morphology
- Statistics & probability
- Physiology
- Cultural studies
- Toxicology
- Polymer science
- Materials science, biomaterials
- Tropical medicine
- Neurosciences
- Genetics & heredity
- Chemistry, applied
- Urban studies
- Operations research & management science
- Biophysics
- Biology, miscellaneous
- Biology
- Acoustics
- Philosophy
- Asian studies
- Physics, condensed matter
- Physics, multidisciplinary
- Anthropology
- Psychiatry
- Psychology
- Psychology, experimental
- Public, environmental & occupational health
- Religion
- Reproductive biology
- Agriculture, multidisciplinary
- Sociology
- Surgery
- Telecommunications
- Imaging science & photographic technology
- Transportation science & technology
- Language & linguistics
- Law
- Logic
- Food science & technology
- Materials science, coatings & films
- Engineering, chemical
- Dermatology
- Mathematics
- Mechanics
- Computer science, interdisciplinary applications
- Microscopy
- Computer science, hardware & architecture
- Communication
- Music
- Clinical neurology
- Nanoscience & nanotechnology
- Neuroimaging
- Nuclear science & technology
