New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
BIOTROPH - Molecular Ecology
A data set for the project ‘BIOTROPH’. The aim of this study was to estimate functional role of the taxonomic diversity of available resources in the field on trophic exposure of small mammals (wood mice ‘Apodemus sylvaticus’) to trace metals (TM; principally cadmium, lead and zinc). The data was ...
CECURE-Contamination of the Environment and Circulation in Urban and Rural areas of Echinococcus multilocularis
A copro-sample collection was created for the CECURE project. The aim of this study was to assess the relative role of carnivore hosts (mainly fox, dog, cat) in the speading and circulation of the parasite Echinococcus multilocularis in the urban and rural environnement in order to assess the ...
Human recreational disturbance effects on chicks stress
Stress hormones, telomere lenght, and reproductive success for breeding bird in the Chaux forest.
DNA Library - CNR Echinococcoses
DNA Library is a database associated to a web interface, created to improve the storage and the life of a biological sample collection, closely related to the research activities of the National Reference Center for Echinococcosis (CNR Echinococcoses, University Hospital of Besançon, France). A ...
Small mammals and arsenic in Salsigne (France)
Provides data on arsenic contamination in soils, exposure and bioaccumulation in small mammals, around a former gold mine extraction site in southern France (Salsigne, Aude). Provides also biometric data. Small mammal species are Apodemus sylvaticus (204), Mus spretus (55), Chionomys nivalis (2), ...
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