New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Pollen analysis - Dizy (Suisse, Vaud), En Delèze
Two series of pollen analyses at En Delèze, Dizy. Natural site: peat bog. Series 1: Samples from three trenches (M20, M25 et M80) Series 2: Drilling with a mechanized Russian core (DZ6) All together, 289 samples analysed and 18 14C dates.
Wikipedia Ranking of World Universities 2017
We present Wikipedia Ranking of World Universities (WRWU) based on analysis of networks of 24 Wikipedia editions collected in May 2017. With PageRank and CheiRank algorithms we determine ranking of universities averaged over cultural views of these editions. The comparison with the Shanghai ranking ...
Wikipedia Ranking of World Universities
We obtained the ranking of the most influential universities in Wikipedia. We analyzed networks of articles associated to 24 language editions of Wikipedia to compute the ranking of world universities using PageRank, CheiRank and 2DRank algorithms. The Wikipedia Ranking of World Universities (WRWU) ...
Pollen analysis - Omisalj (Croatia)
Pollen analysis conducted in 2018 from a sediment core recovered in 2016 (OMISALJ-2016) at Omisalj, Krk Island.
Pollen analysis - Osor (Croatia)
Pollen analysis conducted in 2018 from a sediment core recovered in 2016 (OSOR-2016) at Osor, Cres Island.
Googlomics: Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks
Signaling pathways represent parts of the global biological network which connects them into a seamless whole through complex direct and indirect (hidden) crosstalk whose structure can change during normal development or in a pathological conditions such as cancer. Advanced methods for ...
Pollen analyses - Les Hôpitaux-Vieux (F-25), La Beuffarde
Pollen analyses conducted in 2017 from a sediment core recovered in 2016 (BEUF-2016) at La Beuffarde, Les Hôpitaux-Vieux.
Pollen analyses - Alba-la-Romaine (F-07), La Grande Terre
Pollen analyses conducted in 2015 from 23 soil samples recovered in 2015 at La Grande Terre, Alba-la-Romaine.
Pollen analyses - L'Auberson (CH-VD), Les Araignys
Pollen analyses conducted in 2017 from a sediment core recovered in 2015 (ARA-2015) at Les Araignys, L'Auberson.
Pollen analyses - Labergement-Sainte-Marie (F-25), Remoray Lake
Pollen analyses conducted in 2017 from a sediment core recovered in 2007 (REM-07) at Remoray Lake.
Bis{(4-methylthio)phenylthio}methane as assembling ligand for the construction of Cu(I) and Hg(II) coordination polymers. Crystal structures and topological (AIM) analysis of the bonding
The novel 1D coordination polymer (CP) [{Cu(μ2-Br)2Cu}(μ-L2)2] CP2 has been obtained by reaction of the tetrakisthioether p-MeSC6H4SCH2SC6H4SMe-p (L2) with CuBr in a 1:2 metal-to ligand ratio. In contrast to the previously described CP [{Cu(μ2-Br)2Cu}(μ-L1)2] CP1 obtained by reaction of the ...
Two-dimensional polymeric [Hg4([mu]2-I)6I2([mu]2-C4S6)]n
The title compound, poly[([mu]2-2H,5H-1,3-dithiolo[4,5-d][1,3]dithiole-2,5-dithione)hexa-[mu]2-iodido-diiodidotetramercury(II)], [Hg4I8(C4S6)]n, represents the first example of a coordination polymer assembled by the [alpha],[alpha]-C4S6 dithione ligand. The HgII ions are four-coordinated in a ...
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