New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Population genetics in a mixed maternity colony of Myotis myotis and M. blythii - Bourg d'Oisans
Individual genotypes from 210 samples arising from 165 individuals of a maternity roost located in Le Bourg d'Oisans (French Alps), hosting Myotis myotis and Myotis blythii individuals. Num = sample identifier, ID = individual identifier, Sampling = Sampling date, Type = bat type (Myotis myotis, ...
Access
Discipline
- Paleontology
- Mathematical & computational biology
- Genetics & heredity
- Crystallography
- Chemistry, organic
- Geosciences, multidisciplinary
- Environmental sciences
- Chemistry, inorganic & nuclear
- Geology
- Water resources
- Geochemistry & geophysics
- Materials science, multidisciplinary
- Microbiology
- Engineering, electrical & electronic
- Ecology
- Engineering, industrial
- Physics, atomic, molecular & chemical
- Computer science, artificial intelligence
- Engineering, mechanical
- Materials science, characterization & testing
- Engineering, multidisciplinary
- Meteorology & atmospheric sciences
- Chemistry, analytical
- Mineralogy
- Multidisciplinary sciences
- Electrochemistry
- Neurosciences
- Energy & fuels
- Plant sciences
- Polymer science
- Statistics & probability
- Archaeology
- Geography, physical
- Chemistry, physical
- Cell biology
- Computer science, information systems
- Zoology
- Astronomy & astrophysics
- Behavioral sciences
- Biochemistry & molecular biology
- Biodiversity conservation
- Clinical neurology
- Computer science, software engineering
- Geography
- Health care sciences & services
- History
- Humanities, multidisciplinary
- Language & linguistics
- Law
- Linguistics
- Music
- Neuroimaging
- Parasitology
- Pathology
- Philosophy
- Physiology
- Psychiatry
- Psychology
- Psychology, experimental
- Robotics
- Sociology