New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Pollen analysis - Dizy (Suisse, Vaud), En Delèze
Two series of pollen analyses at En Delèze, Dizy. Natural site: peat bog. Series 1: Samples from three trenches (M20, M25 et M80) Series 2: Drilling with a mechanized Russian core (DZ6) All together, 289 samples analysed and 18 14C dates.
Interactions of pharmaceutical companies with world countries, cancers and rare diseases from Wikipedia network analysis
Using the English Wikipedia network of more than 5 million articles we analyze interactions and interlinks between the 34 largest pharmaceutical companies, 195 world countries, 47 rare renal diseases and 37 types of cancer. The recently developed algorithm of reduced Google matrix (REGOMAX) allows ...
Pollen analysis - Omisalj (Croatia)
Pollen analysis conducted in 2018 from a sediment core recovered in 2016 (OMISALJ-2016) at Omisalj, Krk Island.
Pollen analysis - Osor (Croatia)
Pollen analysis conducted in 2018 from a sediment core recovered in 2016 (OSOR-2016) at Osor, Cres Island.
Population genetics in a mixed maternity colony of Myotis myotis and M. blythii - Bourg d'Oisans
Individual genotypes from 210 samples arising from 165 individuals of a maternity roost located in Le Bourg d'Oisans (French Alps), hosting Myotis myotis and Myotis blythii individuals. Num = sample identifier, ID = individual identifier, Sampling = Sampling date, Type = bat type (Myotis myotis, ...
Googlomics: Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks
Signaling pathways represent parts of the global biological network which connects them into a seamless whole through complex direct and indirect (hidden) crosstalk whose structure can change during normal development or in a pathological conditions such as cancer. Advanced methods for ...
Pollen analyses - Les Hôpitaux-Vieux (F-25), La Beuffarde
Pollen analyses conducted in 2017 from a sediment core recovered in 2016 (BEUF-2016) at La Beuffarde, Les Hôpitaux-Vieux.
Pollen analyses - Alba-la-Romaine (F-07), La Grande Terre
Pollen analyses conducted in 2015 from 23 soil samples recovered in 2015 at La Grande Terre, Alba-la-Romaine.
Pollen analyses - L'Auberson (CH-VD), Les Araignys
Pollen analyses conducted in 2017 from a sediment core recovered in 2015 (ARA-2015) at Les Araignys, L'Auberson.
Pollen analyses - Labergement-Sainte-Marie (F-25), Remoray Lake
Pollen analyses conducted in 2017 from a sediment core recovered in 2007 (REM-07) at Remoray Lake.
Dendrochronology, dendroarchaeology, dendroclimatology of Silver Fir in Jura mountains (France)
Siver Fir (Abies alba) individual tree-ring width data bank.
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