New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Pressure-Temperature quantification of continental crustal hydration - Colorado Plateau
Data acquired in collaboration with the University of Boulder in Colorado (U.S.A.) for the understanding of the Colorado Plateau elevation. These data sets include mineralogical, petrological, chemical, pressure-temperature modelisation and density evolution.
Suretta nappe shear zones
The database "Suretta nappe shear zones" contains petrological, structural and microtextural data of millimetre-scale shear zones from the Roffna rhyolite (Suretta nappe, Eastern Alps, Switzerland). The data consist of structural orientations, optical and electronic images of the mineralogy of the ...
Clay mineralogical and geochemical expressions of the "Late Campanian Event" in the Aquitaine and Paris basins (France): Palaeoenvironmental implications
Campanian sediments from two French sedimentary basins were studied, using clay mineralogy and stable isotope (δ13C and δ18O) geochemistry, in order to investigate the Late Campanian Event. The clay fraction of the Campanian sediments from the Tercis-les-Bains section (Aquitaine Basin) and from the ...
Continental weathering as a driver of Late Cretaceous cooling: new insights from clay mineralogy of Campanian sediments from the southern Tethyan margin to the Boreal realm
New clay mineralogical analyses have been performed on Campanian sediments from the Tethyan and Boreal realms along a palaeolatitudinal transect from 45° to 20°N (Danish Basin, North Sea, Paris Basin, Mons Basin, Aquitaine Basin, Umbria-Marche Basin and Tunisian Atlas). Significant terrigenous ...
Access
Discipline
- Paleontology
- Mathematical & computational biology
- Zoology
- Mineralogy
- Crystallography
- Chemistry, organic
- Chemistry, inorganic & nuclear
- Materials science, multidisciplinary
- Microbiology
- Cell biology
- Chemistry, physical
- Environmental sciences
- Ecology
- Engineering, mechanical
- Engineering, electrical & electronic
- Engineering, environmental
- Geology
- Geosciences, multidisciplinary
- Materials science, characterization & testing
- Parasitology
- Engineering, industrial
- Mycology
- Engineering, multidisciplinary
- Computer science, artificial intelligence
- Forestry
- Water resources
- Polymer science
- Biodiversity conservation
- Computer science, software engineering
- Marine & freshwater biology
- Materials science, biomaterials
- Health care sciences & services
- Chemistry, applied
- Surgery
- Mechanics
- Medical informatics
- Electrochemistry
- Robotics
- Music
- Biochemistry & molecular biology
- Neurosciences
- Ornithology
- Psychology, experimental
- Pathology
- Physics, atomic, molecular & chemical
- Energy & fuels
- Dermatology
- Computer science, information systems
- Infectious diseases
- Language & linguistics