New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Pollen analysis - Montlebon (F-25), Sur la Vigne 1 (Morteau A)
Natural site: wet meadow. 99 palynological samples + 4 radiocarbon datings. Drilling of 28.10 meters length.
Pollen analysis - Montlebon (F-25), La Vigne 2
Natural site: wet meadow. 22 palynological samples. From 3,90 to 18,85 meters length: extension of Morteau Stade and Sur la Seigne transect lines.
Pollen analysis - Lavancia-Epercy (F-39), Dortan travertine quarry
Natural site: travertine quarry ("Tuff of Dortan"). 3 palynological samples + 1 radiocarbon dating: 9100 ± 180 BP.
Pollen analysis - Montlebon (F-25), Transect S4
Natural site: wet meadow. 6 palynological samples. From 10.20 to 13.20 meters. Atypical results. Extension of Morteau Stade et Sur la Seigne transect lines.
Pollen analysis - Montlebon (Morteau-Montlebon) (F-25), Transects II-6, II-7 et III-7
Natural site; wet meadow. 14 palynological samples. Approximate geographical coordinates: 3 transect lines.
Pollen analysis - Montlebon (F-25), Sur La Seigne
Natural site: wet meadow. 58 palynological samples + 2 radiocarbon datings. 10,40 meters length.
Pollen analysis - Montlebon (F-25), Transect S3
Natural site: wet meadow. 24 palynological samples. From 4.40 to 25,70 meters length: extension of Morteau Stade and Sur la Seigne transect lines.
Pollen analysis - Morteau (F-25), Moulin Bournez
Natural site; weat meadow. 126 palynological samples + 2 radiocarbon datings. 33,57 meters length drilling.
Pollen analysis - Morteau (F-25), Transect S2
Natural site; weat meadow. 16 palynological samples. Many drillings along a transect ligne: 6.0 to 12.45 meters length.
Pollen analysis - Morteau (F-25), Transect S1
Natural site; weat meadow. 18 palynological samples. Many drillings along a transect ligne: 4.20 to 12.30 meters length.
Pollen analysis - Morteau (F-25), Stade
Natural site; weat meadow. 62 palynological samples. 12 meters length drilling.
Pollen analysis - Arcenant (F-21), Les Berthières (Merovingian necropolis)
Archaeological site: Merovingian tombs. 2 palynological samples.
Pollen analysis - Pont-du-Navoy (F-39), lower river terrace of the Ain river
Natural site. Geological section in pleniglacial varves. 3 palynological samples.
Pollen analysis - Ranchot (F-39), Abri des Cabones 1984 + Châteauneuf
Archaeological excavation: rock shelter. 5 palynological samples. 1 sample in "Abri de Chateauneuf" (47°09'13.28/5°54'14.05). First analysis: J. Heim, 1979.
Pollen analysis - Mirebel (F-39), Les Granges Bruant
Natural site. Organic level into the lower river terrace of the Ain river. 3 palynological samples. Presence of Fagus and Juglans pollen grains (= pollution).
Pollen analysis - Morre (La Vèze) (F-25), La Tourbière (Marais de Saône), 1984
Natural site; marsh. 4 palynological samples. Very bad conservation. Deep drilling in clay levels.
Pollen analysis - Ney (F-39), Varves de Ney, Les Prés des Rousserots
Natural site: geological section border on the Ain river. 2 palynological samples.
Pollen analysis - Châtillon (F-39), Les Ebalèves (varves)
Natural site. Geological section border on the Ain river. 25 palynological samples very low in pollen grains. Other analysis by Bohneke (1987) and Duverne (1958).
Pollen analysis - Charcier (F-39), En Bourand (Varves)
Natural site. Geological section border on the Ain river. Only one nearly sterile palynological sample.
Pollen analysis - Châtillon (F-39), Au Touillon (Collondon varves)
Natural site. Geological section along the Ain river. Only one palynological sample.
World influence of infectious diseases from Wikipedia network analysis
We consider the network of 5416537 articles of English Wikipedia of 2017. Using the recent reduced Google matrix (REGOMAX) method we construct the reduced network of 230 articles (nodes) of infectious diseases and 195 articles of world countries. This method generates the reduced directed network ...
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