New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
DCF77 time of flight measurement
DCF77 is a Very Low Frequency (VLF) emitter located in Mainflingen, Germany, about 400 km away from Besançon, France. The objective of the collected data is to measure the time of flight of the 77.5 kHz signal with respect to GPS 1 PPS used as reference, and assess the dependence with ionospheric ...
CT scanners and surface scanners of primate crania
The dataset is composed of several hundreds of primate skulls. They have been scanned with micro CT scanner and surface scanners. The region of interest of this dataset is the cranial base so the muzzle and the anterior part could be missing.
Googlomics: Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks
Signaling pathways represent parts of the global biological network which connects them into a seamless whole through complex direct and indirect (hidden) crosstalk whose structure can change during normal development or in a pathological conditions such as cancer. Advanced methods for ...
Wildlife Ecotoxicology - Small mammals - Metaleurop Nord
This database presents morphometric (body size and mass, organ mass or size...) and ecotoxicological (concentrations of pollutants in some organs, various biomarkers) data from small mammals (voles, mice, shrews...) captured in the surroundings of a former lead and zinc smelter named Metaleurop Nord ...
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